Precision functional MRI mapping reveals distinct connectivity patterns for depression associated with traumatic brain injury

JOURNAL ARTICLE published 5 July 2023 in Science Translational Medicine

Authors: Shan H. Siddiqi | Sridhar Kandala | Carl D. Hacker | Heather Bouchard | Eric C. Leuthardt | Maurizio Corbetta | Rajendra A. Morey | David L. Brody

Mitochondrial augmentation of hematopoietic stem cells in children with single large-scale mitochondrial DNA deletion syndromes

JOURNAL ARTICLE published 21 December 2022 in Science Translational Medicine

Authors: Elad Jacoby | Omer Bar-Yosef | Noah Gruber | Einat Lahav | Nira Varda-Bloom | Yoav Bolkier | Diana Bar | Moriya Ben-Yakir Blumkin | Sharon Barak | Etzyona Eisenstein | Jaana Ahonniska-Assa | Tamar Silberg | Tal Krasovsky | Orly Bar | Neta Erez | Bella Bielorai | Hana Golan | Benjamin Dekel | Michal J. Besser | Gat Pozner | Hanan Khoury | Alan Jacobs | John Campbell | Eli Herskovitz | Noa Sher | Natalie Yivgi-Ohana | Yair Anikster | Amos Toren

Staphylococcus aureus α toxin potentiates opportunistic bacterial lung infections

JOURNAL ARTICLE published 9 March 2016 in Science Translational Medicine

Research funded by NIH (R01 AI087674)

Authors: Taylor S. Cohen | Jamese J. Hilliard | Omari Jones-Nelson | Ashley E. Keller | Terrence O’Day | Christine Tkaczyk | Antonio DiGiandomenico | Melissa Hamilton | Mark Pelletier | Qun Wang | Binh An Diep | Vien T. M. Le | Lily Cheng | JoAnn Suzich | C. Kendall Stover | Bret R. Sellman

The need for global regulatory harmonization: A public health imperative

JOURNAL ARTICLE published 11 May 2016 in Science Translational Medicine

Authors: Elias Zerhouni | Margaret Hamburg

Metabolic adaptation of ovarian tumors in patients treated with an IDO1 inhibitor constrains antitumor immune responses

JOURNAL ARTICLE published 16 March 2022 in Science Translational Medicine

Authors: Kunle Odunsi | Feng Qian | Amit A. Lugade | Han Yu | Melissa A. Geller | Steven P. Fling | Judith C. Kaiser | Andreanne M. Lacroix | Leonard D’Amico | Nirasha Ramchurren | Chihiro Morishima | Mary L. Disis | Lucas Dennis | Patrick Danaher | Sarah Warren | Van Anh Nguyen | Sudharshan Ravi | Takemasa Tsuji | Spencer Rosario | Wenjuan Zha | Alan Hutson | Song Liu | Shashikant Lele | Emese Zsiros | A. J. Robert McGray | Jessie Chiello | Richard Koya | Thinle Chodon | Carl D. Morrison | Vasanta Putluri | Nagireddy Putluri | Donald E. Mager | Rudiyanto Gunawan | Martin A. Cheever | Sebastiano Battaglia | Junko Matsuzaki

Short-course combination treatment for experimental chronic Chagas disease

JOURNAL ARTICLE published 13 December 2023 in Science Translational Medicine

Authors: Silvia González | Richard J. Wall | John Thomas | Stephanie Braillard | Gino Brunori | Isabel Camino Díaz | Juan Cantizani | Sandra Carvalho | Pablo Castañeda Casado | Eric Chatelain | Ignacio Cotillo | Jose M. Fiandor | Amanda Fortes Francisco | David Grimsditch | Martine Keenan | John M. Kelly | Albane Kessler | Chiara Luise | Jon J. Lyon | Lorna MacLean | Maria Marco | J. Julio Martin | Maria S. Martinez Martinez | Christy Paterson | Kevin D. Read | Angel Santos-Villarejo | Fabio Zuccotto | Susan Wyllie | Tim J. Miles | Manu De Rycker

White matter changes linked to visual recovery after nerve decompression

JOURNAL ARTICLE published 10 December 2014 in Science Translational Medicine

Authors: David A. Paul | Elon Gaffin-Cahn | Eric B. Hintz | Giscard J. Adeclat | Tong Zhu | Zoë R. Williams | G. Edward Vates | Bradford Z. Mahon

Regeneration of neuromuscular synapses after acute and chronic denervation by inhibiting the gerozyme 15-prostaglandin dehydrogenase

JOURNAL ARTICLE published 11 October 2023 in Science Translational Medicine

Authors: Mohsen A. Bakooshli | Yu Xin Wang | Elena Monti | Shiqi Su | Peggy Kraft | Minas Nalbandian | Ludmila Alexandrova | Joshua R. Wheeler | Hannes Vogel | Helen M. Blau

Epidemiological dynamics of enterovirus D68 in the United States and implications for acute flaccid myelitis

JOURNAL ARTICLE published 10 March 2021 in Science Translational Medicine

Research funded by National Institute of Allergy and Infectious Diseases (K23AI128069) | National Institute of Allergy and Infectious Diseases (K23AI128069) | Wellcome (216427/Z/19/Z) | Wellcome (216427/Z/19/Z) | Royal Society (216427/Z/19/Z)

Authors: Sang Woo Park | Margarita Pons-Salort | Kevin Messacar | Camille Cook | Lindsay Meyers | Jeremy Farrar | Bryan T. Grenfell

Chronic administration of an HDAC inhibitor treats both neurological and systemic Niemann-Pick type C disease in a mouse model

JOURNAL ARTICLE published 17 February 2016 in Science Translational Medicine

Authors: Md. Suhail Alam | Michelle Getz | Kasturi Haldar

Variants in ALDH1A2 reveal an anti-inflammatory role for retinoic acid and a new class of disease-modifying drugs in osteoarthritis

JOURNAL ARTICLE published 21 December 2022 in Science Translational Medicine

Authors: Linyi Zhu | Pragash Kamalathevan | Lada A. Koneva | Jadwiga Miotla Zarebska | Anastasios Chanalaris | Heba Ismail | Akira Wiberg | Michael Ng | Hayat Muhammad | John Walsby-Tickle | James S.O. McCullagh | Fiona E. Watt | Stephen N. Sansom | Dominic Furniss | Matthew D. Gardiner | Tonia L. Vincent | The Oxford Hand Surgical Team

Uncoupling interferon signaling and antigen presentation to overcome immunotherapy resistance due to JAK1 loss in melanoma

JOURNAL ARTICLE published 14 October 2020 in Science Translational Medicine

Research funded by National Institutes of Health (T32-CA009120) | National Cancer Institute (CA197633) | National Cancer Institute (CA168585) | National Cancer Institute (P01 CA244118) | Ressler Family Fund (N/A) | National Center for Advancing Translational Sciences (TR001882)

Authors: Anusha Kalbasi | Mito Tariveranmoshabad | Kevin Hakimi | Sarah Kremer | Katie M. Campbell | Juan M. Funes | Agustin Vega-Crespo | Giulia Parisi | Ameya Champekar | Christine Nguyen | Davis Torrejon | Daniel Shin | Jesse M. Zaretsky | Robert D. Damoiseaux | Daniel E. Speiser | Pedro P. Lopez-Casas | Marisol Quintero | Antoni Ribas

A Preclinical Xenograft Model Identifies Castration-Tolerant Cancer-Repopulating Cells in Localized Prostate Tumors

JOURNAL ARTICLE published 29 May 2013 in Science Translational Medicine

Authors: Roxanne Toivanen | Mark Frydenberg | Declan Murphy | John Pedersen | Andrew Ryan | David Pook | David M. Berman | Renea A. Taylor | Gail P. Risbridger | Australian Prostate Cancer BioResource

Inhibition of TET1 prevents the development of osteoarthritis and reveals the 5hmC landscape that orchestrates pathogenesis

JOURNAL ARTICLE published 15 April 2020 in Science Translational Medicine

Research funded by NIH Office of the Director (R01 AR070865-01) | NSF Office of the Director (GRFP)

Authors: Piera Smeriglio | Fiorella C. Grandi | Spoorthi Davala | Venkata Masarapu | Pier Francesco Indelli | Stuart B. Goodman | Nidhi Bhutani

Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins

JOURNAL ARTICLE published 14 September 2022 in Science Translational Medicine

Authors: Junli Gao | Quinlan T. Mewborne | Amandeep Girdhar | Udit Sheth | Alyssa N. Coyne | Ritika Punathil | Bong Gu Kang | Morgan Dasovich | Austin Veire | Mariely DeJesus Hernandez | Shuaichen Liu | Zheng Shi | Ruxandra Dafinca | Elise Fouquerel | Kevin Talbot | Tae-In Kam | Yong-Jie Zhang | Dennis Dickson | Leonard Petrucelli | Marka van Blitterswijk | Lin Guo | Ted M. Dawson | Valina L. Dawson | Anthony K. L. Leung | Thomas E. Lloyd | Tania F. Gendron | Jeffrey D. Rothstein | Ke Zhang

Prime and target immunization protects against liver-stage malaria in mice

JOURNAL ARTICLE published 26 September 2018 in Science Translational Medicine

Authors: Anita Gola | Daniel Silman | Adam A. Walters | Saranya Sridhar | Stefan Uderhardt | Ahmed M. Salman | Benedict R. Halbroth | Duncan Bellamy | Georgina Bowyer | Jonathan Powlson | Megan Baker | Navin Venkatraman | Ian Poulton | Eleanor Berrie | Rachel Roberts | Alison M. Lawrie | Brian Angus | Shahid M. Khan | Chris J. Janse | Katie J. Ewer | Ronald N. Germain | Alexandra J. Spencer | Adrian V. S. Hill

β-amyloid can’t go with the flow

JOURNAL ARTICLE published 7 December 2016 in Science Translational Medicine

Authors: Brendan P. Lucey

Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson’s disease

JOURNAL ARTICLE published 8 June 2022 in Science Translational Medicine

Authors: Danna Jennings | Sarah Huntwork-Rodriguez | Anastasia G. Henry | Jennifer C. Sasaki | René Meisner | Dolores Diaz | Hilda Solanoy | Xiang Wang | Elvira Negrou | Vitaliy V. Bondar | Rajarshi Ghosh | Michael T. Maloney | Nicholas E. Propson | Yuda Zhu | Romeo D. Maciuca | Laura Harris | Angela Kay | Peter LeWitt | T. Alex King | Drew Kern | Aaron Ellenbogen | Ira Goodman | Andrew Siderowf | Jason Aldred | Omid Omidvar | Shababa T. Masoud | Sonnet S. Davis | Annie Arguello | Anthony A. Estrada | Javier de Vicente | Zachary K. Sweeney | Giuseppe Astarita | Marie T. Borin | Bradley K. Wong | Harvey Wong | Hoang Nguyen | Kimberly Scearce-Levie | Carole Ho | Matthew D. Troyer

Smaller, Softer, Safer, Smarter Robots

JOURNAL ARTICLE published 6 November 2013 in Science Translational Medicine

Authors: Robert Wood | Conor Walsh

Targeted Delivery of PLK1-siRNA by ScFv Suppresses Her2 ⁺ Breast Cancer Growth and Metastasis

JOURNAL ARTICLE published 18 April 2012 in Science Translational Medicine

Authors: Yan-dan Yao | Tian-meng Sun | Song-yin Huang | Shuang Dou | Ling Lin | Jia-ning Chen | Jian-bin Ruan | Cheng-qiong Mao | Feng-yan Yu | Mu-sheng Zeng | Jian-ye Zang | Qiang Liu | Feng-xi Su | Peter Zhang | Judy Lieberman | Jun Wang | Erwei Song